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Fresh vs. Frozen embryo transfer

When in vitro fertilization (IVF) was first developed, fresh embryo transfer was the only type of transfer that was available. This is mainly because the cryopreservation technology was still underdeveloped. 

After decades of research, the first embryo was successfully transferred using cryopreservation techniques and advanced reproductive technologies. This type of preserved embryo transfer is called frozen embryo transfer.

When patients undergo IVF, they face confusion between choosing fresh embryo transfer or frozen embryo transfer. This choice should not be made mainly based on timing; they should also consider other factors like success rate, emotional well-being, and overall outcomes. 

This blog will help you understand the differences between these two methods and help the patients make informed decisions according to their needs and situations.

Understanding embryo transfer

The last step of IVF is embryo transfer. It mainly involves transferring embryos into the uterus after they have been fertilized and cultured in the laboratory. The transfer timing and condition of the uterus are important for the success of pregnancy. 

In IVF, eggs will be taken from the ovaries and fertilized with sperm in a controlled environment. The resulting embryo will be cultured for a few days until it reaches the blastocyst stage, which is considered optimal for transfer. 

Before the transfer, the uterus will be maintained and prepared for receiving the embryo. The uterine lining needs to be receptive to the embryo for implantation. 

It is important to identify the timing of embryo transfer. Fresh embryo transfer normally takes place a few days after the egg is retrieved and the blastocyst stage is obtained. It occurs when the fertilized eggs are transferred into the uterus of women in the same IVF cycle in which eggs are retrieved and fertilized. 

Meanwhile, in the frozen embryo, transfer timing can be flexible allowing for optimal synchronization with the uterine environment. In the case of frozen embryo transfer, the embryos are frozen after fertilization and can be stored for transfer in the later part of the IVF cycle.

The difference between fresh and frozen embryo transfers

Fresh embryo transfer

Fresh embryo transfer normally takes place 3 to 5 days after egg retrieval. They are fertilized with sperm in the laboratory, which results in the formation of embryos. This process must be monitored closely. 

The main advantage of fresh embryo transfer is that there is a short time to pregnancy since there is only a 5-day waiting period between the retrieval of the egg and embryo transfer into the uterus. Also, many insurance companies do not cover the cryopreservation cost, so some patients will choose fresh embryo transfer because of financial reasons. 

There are also some contraindications for using fresh embryo transfer. That is, if the progesterone level of the patient is increased, then fresh transfer cannot be done as it will affect the embryo implantation negatively. Similarly, if the patient has a high risk of experiencing hyperstimulation from the medications that are used for ovulation induction, the transfer of a fresh embryo will be dangerous for the patient.

Frozen embryo transfer

The frozen embryo transfer process can be done anytime the patient wishes. After the patient is ready for the transfer, they will be given medications that can act like a natural cycle, and the frozen embryo transfer date will be coordinated according to the cycle for optimization of implantation.

Frozen embryo transfer is needed if the patient likes to check for genetic abnormalities in embryos. Shortly after the retrieval of eggs, preimplantation genetic testing will be carried out. 

A small sample of the embryo will be taken, and that sample with the DNA of the embryo will be assessed for chromosomal and genetic abnormalities. After the preimplantation genetic testing, embryologists can choose the chromosomally normal embryos for transfer. The rate of pregnancy success can be improved by transferring healthy embryos.

Frozen embryo transfer can also be used for subsequent pregnancy even after years since the embryos can be stored indefinitely. Also, if the patient likes to preserve fertility because of age, cancer treatment, or any other reasons, embryos can be preserved for later use, and when ready, frozen embryo transfer can be performed.

Success rates for fresh and frozen embryos of transfers

Various studies show a higher success rate when using frozen embryos than fresh embryos during embryo transfer. Some of the studies are,

New England Journal of Medicine: In a study published in 2018, it has been identified that women with infertility issues that are related to polycystic ovarian syndrome have higher live birth rates when frozen embryo transfer is carried out.

British Medical Journal: In the study carried out in 2020. It has been identified that there are no high ongoing pregnancy or live birth rates in women who are using frozen embryo transfer. This is mainly based on the patients having regular periods and through gonadotropin-releasing hormones.

Maternal age: A study has also identified that high-quality and healthy embryos can be used on older women for embryo transfer. There are no adverse effects on the implantation or live birth rates.

Fresh vs. frozen blastocyst transfer

The embryos that are developed for 5 to 6 days after fertilization are called blastocysts. The transfer of blastocysts, whether they can be frozen or fresh, can lead to a high rate of success when compared to the transfer of younger embryos. This is because they are close to the stage at which the implantation occurs naturally in the body.

Why is frozen embryo transfer better?

Various studies suggest that frozen embryo transfer has several advantages over fresh embryo transfer, including lower rates of preterm labor and higher birth weights. Along with that, the frozen transfer cycle will allow the body to recover in stimulation, which leads to a more favorable environment for implantation. Some other advantages are,

  • Frozen embryo transfer typically costs less compared to fresh embryo transfer.
  • Frozen embryo transfer can help preserve your fertility and help you plan for pregnancy when you are ready. 
  • It will give less mental and physical stress to the body of the woman.
  • Frozen embryo transfer normally mimics the natural cycle.
  • A frozen embryo cycle can also be used to check the gender and any genetic abnormalities in the embryo. 

In various studies, it has been identified that live birth rates were slightly higher in frozen embryo transfer when compared to fresh embryo transfer. Also, frozen embryo transfer may provide a slight advantage in a successful pregnancy.

Conclusion

Going through IVF treatment can be challenging, but if it is filled with knowledge and guided by a trusted professional, it can help you to make an informed decision that can best suit your situation. 

Whether you select fresh embryo transfer or frozen embryo transfer, always remember that each journey for parenthood is unique.

FAQs

Factors include patient age, health conditions, uterine readiness, and personal preferences.

FET may involve longer waiting periods, which can be emotionally challenging for some patients.

Insurance coverage for FET varies, and some plans may not cover the costs of cryopreservation.

Yes, FET can be timed to coincide with a patient’s natural cycle for optimal results.

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When is Frozen Embryo Transfer Done After Period?

For many couples, one of the common options available for successfully becoming pregnant is in vitro fertilization (IVF). However, IVF has a specific timeline, mainly for frozen embryo transfer, which makes most people confused as to when the particular process takes place. 

Frozen embryo transfer is an important component of assisted reproductive technology. The timing of the transfer is significant for making sure that the uterine environment is favorable for embryos to implant and grow. 

This blog helps to inform the readers about the optimal timing for frozen embryo transfer after a period.

Understanding the Menstrual Cycle and Endometrial Preparation

The menstrual cycle can be classified into various phases, and each phase plays an important role in the preparation of the body during pregnancy. 

Follicular phase

This phase starts on the first day of menstruation and ends at the start of the ovulation period. In this phase, the pituitary gland will release a follicle-stimulating hormone (FSH) that stimulates the growth of the ovarian follicle. When the follicles mature, they will produce estrogen that makes the endometrial line thick for preparation for potential pregnancy.

Ovulation phase

The ovulation happens at the middle of the menstrual cycle when the mature eggs are released from the ovary.  The increased production of luteinizing hormone (LH) triggers the ovulation process.  This is an important timing for frozen embryo transfer as, at this stage, the endometrium will reach its peak for receptivity after a few days of ovulation.

Luteal phase

After the ovulation process, the luteal phase starts. Here, the ruptured follicles transform into corpus luteum and secrete progesterone. Progesterone helps stabilize the endometrial lining and make it more receptive to implantation. 

This phase is significant for frozen embryo transfer cycles, as endometrium must be prepared adequately with progesterone for the successful implantation of the embryo. 

Endometrial Lining and Its Role in FET:

The thickness of the endometrial lining and its quality are vital for the successful implantation of embryos. Normally, the thickness must be between 7 mm to 14 mm at the time of transfer. 

Timing of Frozen Embryo Transfer Post-Menstruation

Determination of Proper Time for FET

Based on the cycle type proper timing will be determined for frozen embryo transfer. The cycles may be natural, medicated, or modified naturally.

Frozen embryo transfer is performed 2 to 7 days after ovulation. This corresponds to approximately 14 to 21 days after the start of menstruation. In a medication cycle, there will be more controlled time and the endometrial lining will be prepared with estrogen and progesterone. 

Timing Varies Depending on the Cycle type

Natural cycle

The timing of the frozen embryo transfer will be aligned with the ovulation of the patient in the natural cycle.  Their ovulation will be monitored carefully with the help of blood tests and ultrasounds. Then the transfer will be carried out during the most respective time of endometrium. 

Medicated cycle

In this cycle, the endometrium will be prepared with the help of hormones and they will not be related to the natural ovulation of the patient. For thickening of endometrium lining estrogen will be given and it is followed by progesterone for stabilization. Based on the time length in which endometrium is with progesterone the timing for embryo transfer will be determined.

Factors Influencing Timing

Various factors that can influence the embryo transfer timing are the menstrual cycle, regularity of the patient, hormone levels, and the doctor’s assessment of endometrial lining. 

If the patient is suffering from irregular periods, then additional monitoring and adjustment will be carried out.  This helps in ensuring that the endometrium is prepared adequately for the embryo transfer. It is also necessary to check the hormone imbalance and correct it during the treatment period. 

FET schedule

Every patient has a different personalized schedule for frozen embryo transfer, mainly based on their specific situation. Healthcare providers will consider their menstrual cycle, hormone levels, and response level to the treatment when determining the best time for frozen embryo transfer. This personalized approach will help increase the chances of successful pregnancy.

Types of Cycles and Their Impact on FET Timing

Frozen embryo transfer timing will be aligned with the natural ovulation of the patient’s natural cycle. The ovulation will be monitored with the help of blood tests and ultrasounds, and then the optimal time for transfer will be determined.  

The main advantage of the natural cycle is that there is less medicine used. However, it needs precise monitoring to make sure that the timing is correct.

The timing of embryo transfer will be more controlled in the medicated cycles than in natural cycles. Estrogen will be used to prepare the endometrium to promote its thickness, and stabilization will be carried out using progesterone. 

This will help create more flexible schedules as embryo transfer timing does not depend upon natural ovulation.  This method is mostly used in patients with irregular menstrual cycles or those who need more control over the timings of their transfer.

The modified natural cycle is a combination of the natural cycle and the medicated cycle. In this method, patients may receive minimal support from hormones to ensure proper endometrial preparation so that the natural process can take place. This method is beneficial for patients who prefer natural processes but need hormonal assistance. 

Factors That May Affect the Timing of FET

  • Thickness of the endometrium
  • Levels of hormones
  • Other health conditions include polycystic ovarian syndrome and thyroid disorders. 

Protocols for Timing FET

The timing for frozen embryo transfer starts at the beginning of the menstrual cycle. In natural cycles, ovulation will be monitored and embryo transfer will be secured at the proper timing after ovulation. 

In the medicated cycle estrogen is given for preparing the endometrium and progesterone to stabilize it. The timing for the embryo transfer will be carefully calculated based on the preparation of hormones and receptivity of endometrial linings. 

Conclusion

The timing for frozen embryo transfer after a period is significant for the success of pregnancy. The menstrual cycle plays a vital role in preparing the endometrium for embryo implantation, and precise timing is required for embryo transfer to be successful.  

It is important to consult the specialist about the best timing and the methods that an individual needs for pregnancy. With proper timing, careful preparation, and expert guidance, the success of frozen embryo transfer pregnancy will be greater.

FAQs

FET is typically done 5-7 days after ovulation, around 14-21 days post-period start.

Yes, FET can be timed with natural ovulation by monitoring hormonal levels and ultrasound.

In a medicated cycle, hormones like estrogen and progesterone prepare the endometrium independently of natural ovulation.

FET timing in a medicated cycle is based on hormone preparation and endometrial response.

Yes, irregular periods may require additional monitoring and adjustments for precise FET timing.

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Preparation Before IUI Procedure

IUI (Intrauterine Insemination) is an important procedure that uses assisted reproductive techniques to help infertile couples achieve pregnancy. It has shown a higher chance of success throughout the years. 

An IUI is done by collecting the sperm from your partner and injecting it directly into your uterus. Your fertility doctor will ensure you have a successful IUI procedure. 

However, you can also do your part and prepare well for the procedure. In this article, we will discuss some useful measures you can take to prepare for IUI and increase your chances of success. 

How To Prepare For An IUI Procedure

Your fertility doctor will assess your condition thoroughly and suggest some measures you need to take before an IUI treatment. These measures can help you nourish your health and fertility, preparing you for the IUI procedure. 

Follow A Healthy And Nutritious Diet

The food you eat will give your body the strength it needs to undergo IUI. You need to eat healthy and nutritious foods to improve your body condition and increase your chances of IUI success. 

Eat foods like fresh fruits, vegetables, whole grains, and other healthy foods. Include nutrients like proteins, healthy fats, carbohydrates, vitamins, and omega-3 fatty acids. 

Avoid unhealthy habits like alcohol, caffeine, eating fried and processed foods, etc. Quitting these unhealthy foods some months before IUI can help you flush out the toxins and stay healthy during the procedure. 

Exercise Regularly

A sedentary lifestyle is one of the major causes of infertility in this generation. You need to keep your body active to regulate metabolism and maintain normal hormone levels. 

Ensure you stay active and do exercises regularly, for at least 30 to 45 minutes a day. Do mild but effective exercises like yoga, meditation, swimming, walking, cycling, zumba, and aerobics. 

You can also do your favorite fun activities to stay physically active. Don’t do intense exercises like weight lifting, HIIT, boxing, etc. They can affect your body and give the opposite effect of what you want. 

Take The Necessary Tests

Follow your doctor’s instructions and take the necessary to determine your fertility condition. These tests include uterine exams, ultrasounds, pelvic exams, blood tests, and screening tests for STIs and other infections.

These tests can help your doctor understand your condition and design a personalized treatment plan for you.

Take Hormonal Injections On Time

Hormonal injections are the first part of IUI. You will be administered injections twice a day for some days. These injections stimulate your ovaries and make them produce more mature eggs. 

You can choose to take these injections or follow a natural ovulation cycle for IUI. Your doctor will determine the best course of action based on your fertility condition. 

Optimize Sperm Parameters

IUI does not only involve only you. Your partner has an equal part in its success. Your partner must undergo a semen analysis before IUI. This test will help doctors analyze your partner’s sperm volume, motility, and morphology. 

If your partner has any infertility issues, you can rectify them and improve his sperm quality. You can start IUI after this for better success. 

Learn About The Procedure

It is normal for you to have doubts and concerns regarding your IUI procedure. Entering the world of fertility treatments can be scary. The financial strains and the invasive procedure can make you have second thoughts. 

The only way to come out of this is to know as much as you can about this procedure. Do your research and consult your doctor regarding the treatment. You can also get in touch with couples who have undergone the procedure before. This can give you a more personalized view of the treatment. 

Monitor Ovulation Regularly

While you are getting ready mentally and physically for IUI, it is also important to monitor your follicular development regularly. Your follicles need to be of optimum size for insemination.

Your doctor will regularly monitor its development. When the follicles are big enough, you will be given hCG injections to trigger ovulation. You will undergo insemination about 12–24 hours later. 

Conclusion

Follow the above steps and prepare yourself for your IUI treatment. A healthy mind and body can help you stay stable throughout the procedure and ensure success. 

Stay in touch with your doctor and contact them in case of any issues. Don’t be careless, and stay safe and healthy throughout the procedure. You will definitely have a higher chance of success. 

FAQs

You will undergo several fertility assessments like uterine exams, ultrasounds, pelvi c exams, blood tests, and screening tests for STIs and other infections. Your partner will also undergo semen analysis and other tests. 

These tests can help your doctor understand your condition and design a personalized treatment plan for you.

Ensure you stay active and do exercises regularly, for at least 30 to 45 minutes a day. Do mild but effective exercises like yoga, meditation, swimming, walking, cycling, zumba, and aerobics. 

Before IUI, your partner will be given a sterile container to collect semen. After collection, your sperm will be washed, and the high-quality sperm will be collected separately into a needle. They will then be injected into your uterus during insemination for fertilization. 

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which is correct IUI after follicle rupture or before

Which Is Correct, IUI After Follicle Rupture Or Before?

IUI (Intrauterine Insemination) is a fertility treatment that many couples prefer as their fertility treatment procedure. It has a high success rate, and the procedure is simple. 

The main factor that determines the success of your IUI procedure is the timing of insemination. Insemination is when healthy, motile sperm are injected into the female uterus. This step helps sperm reach the eggs easily for fertilization. 

Fertility doctors determine insemination timing based on when your egg follicles will rupture. In this article, we will discuss whether IUI is done before or after follicle rupture. We will also discuss which method has the highest chance of success. 

When Is Insemination Done: Before Or After Follicle Rupture?

Insemination is typically done after follicle rupture. Insemination is the most important procedure in IUI. So, your doctors will make sure that there are mature eggs available in your fallopian tubes when the sperm is released into your uterus. 

Your doctors will track your ovulation to determine when your follicle will rupture. Whether you undergo a natural cycle IUI or use hormonal injections, your doctors will regularly monitor your follicle development. 

When the follicles reach an optimum size, you will be administered hCG injections to induce follicle rupture. It will take 12–24 hours for the eggs to be released after the injection. Insemination around this time can ensure that eggs are available for fertilization. 

Single IUI Vs. Double IUI

When insemination is done two times in a single IUI cycle, it is called single and double IUI. Typically, you will be inseminated two times, before the follicle rupture and after the follicle rupture. 

This is done for couples who have a very low chance of success. Inseminating two times increases the volume of sperm in the uterus and increases the chances of fertilization. 

Below is the step by step process of how a single and double IUI is done. 

  • Your follicles will be monitored throughout the ovulation cycle. 
  • When they reach a certain size, you will be administered hCG injections to induce follicle rupture. 
  • Your first insemination (single IUI) will be performed about 12–24 hours after the injection. 
  • If the follicles do not rupture during this period, you will undergo another insemination procedure after some time. 
  • Your follicles will be monitored for another 12–24 hours and your second insemination will be performed. 

The Importance Of Timing In IUI Insemination

As we discussed, timing is the main factor that determines IUI’s success. Your doctor needs to time your ovulation and release sperm for fertilization. 

Your egg will stay alive for about 24 hours (about 1 day) after it is released from the follicles. This is called the fertility window. The sperm can stay alive in the uterus for about 4–5 days. 

Your fertility doctor must take the egg’s and sperm’s lifespan into account while determining the timing of insemination. Doing it too early or too late can impact IUI success. 

Conclusion

Your fertility doctor will routinely monitor your follicle development and decide the right time for insemination. Doing it after follicle rupture can increase success rate. 

Even if the eggs are not released during insemination, you can undergo double IUI during the same IUI cycle and increase chances of fertilization. So, don’t worry about IUI failure. Your doctor will do all they can to ensure a successful pregnancy. So, stay positive and hope for the best. 

FAQs

You can use an ovulation predictor kit (OPK) to track ovulation at home. These kits measure the Luteinizing Hormone (LH) in your urine. LH levels increase during ovulation. Your kit can identify the surge in LH hormones and indicate ovulation.

Below are some of the most common signs of ovulation.

  • Changes in cervical mucus
  • Increase in basal body temperature (BBT)
  • Mild cramping in the abdomen
  • Breast tenderness

Insemination occurs around the 14th day of your IUI cycle. This is the time when your eggs will be mature enough to be released from the follicles.

Consider the day of insemination as day 1. Implantation will occur around day 5 or 6 when the fertilized egg reaches the uterus and implants in it.

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how many times IUI before IVF

How Many Times IUI Before IVF

IUI is a fertility process that couples undergo to conceive. Additionally, IVF is another assisted fertility process that helps in pregnancy. There is always confusion about how many IUIs one should undergo before shifting to IVF. 

If you are looking for answers, then this blog clears up the doubts and helps you to take a step closer to parenthood. 

IUI-Intrauterine Insemination

The IUI procedure begins after checking the medical condition of both males and females. The semen is tested for male analysis, and hormone levels are analyzed for women.

The IUI process includes inserting the semen into the uterus. This procedure is carried out specifically during the time nearing the ovulation process. IUI helps to reduce the distance between the sperm and the egg. An IUI is carried out without anesthesia under the guidance of an ultrasound. 

When is an IUI done?

An IUI is carried out under certain conditions accepted by the healthcare professional. Some of the conditions are described below:

  • Male Factor Infertility: This happens if the sperm has low to average sperm motility, low concentration, and abnormal sperm shape and size. During sperm diagnosis, the high-quality sperm are separated for the next steps. 
  • Minor Ovulation Problems: The IUI is chosen for women with mild ovulation issues caused by PCOS.
  • If the cervix is hostile to sperm or the mucus is scanty.
  • If the sperm has antibodies
  • If the couple’s health is good in reproductive health, but they find difficulty in conception. 
  • If any one of the partners has Hepatitis C, HIV, or Hepatitis B
  • If the couple uses donor sperm 
  • If intercourse is not possible due to medical conditions.

Factors Influencing IUI Success

Several factors play a crucial role in determining the success of an IUI. Some of the factors are explained below:

Women Age: Age is a crucial factor that determines a woman’s fertility. Women who are over 35 years of age have a low success rate in IUI compared to IVF. This is because as age reaches 30 or above, the quality of the egg declines, making it hard to conceive through IUI. In these cases, IVF treatment is the best possible alternative. 

Reason for Infertility: The cause of infertility is vital in understanding the success rate of IUI. Couples who have mild male infertility, cervical issues, or unexplained infertility are suitable for IUI. On the other hand, if there is a block in the fallopian tube, male infertility, or any other problem in the uterus, then IVF is the best option for conception.

Infertility Duration: The duration of the period the couple is trying to conceive plays an important role. If the couple is trying to conceive for more than two years, then it is important to choose IVF.

Ovarian Reserve: The number of eggs available in the ovaries determines the type of fertilization. If the woman has a high quantity of eggs, then IUI will give results. However, if there is only a minimum quality of egg, then they should be harvested and kept in laboratory conditions for fertilization, leading to choosing an IVF procedure. 

History of Pregnancy: In case you had a previous pregnancy, the history of those conceptions is crucial. Additionally, couples who have miscarriages or failed IUI should choose IVF.

When to Stop IUI and Switch to IVF?

All fertility treatments, irrespective of IUI or IVF, are an emotional and physical process. Additionally, artificial fertility processes are quite expensive. Hence, it is important to understand when to switch from IUI to IVF.

Number of Cycles Needed Before IVF

It is important to understand the IUI cycles that one needs before IVF. Some of the general guidelines and information are listed below:

Recommendations

Generally, IUI is successful after three to four cycles. Health specialists recommend at least three to six cycles before transferring to IVF. This is based on the success rate. If the couples are not conceived after four cycles, then the chances of success decrease.

Age-Based Guidelines

If there are no underlying conditions of women’s infertility and they are under 35 years of age, then the physician takes up to six cycles of IUI before an IVF. Women over 35 years of age are recommended to undergo only three to four cycles before switching to IVF. This occurs due to the reduction in quality and quantity respective to age. 

Cost

IUI is cheaper compared to IVF. This can be one of the driving factors to try more IUI. However, the overall cost of all the IUI cycles should be considered. More IUI cycles mean that they are not successful and you should switch to IVF. 

Emotional and Physical Support

In general, fertility care is not a cakewalk. It is emotionally and physically demanding as couples wait for positive signs every cycle. Hence, this takes a mental toll on the couple’s well-being. This can also be one of the major factors to consider before moving to an IVF procedure. 

Factors to Consider Before Moving to IVF

The primary factor to look into after completing a few IUI cycles is the success rate. Women over 35 years of age with underlying problems should opt for IVF sooner to be able to conceive. 

Moreover, finance is an important sector that rules the decision-making sector. IVF is a faster option to conceive when compared to IUI. Being emotionally available and getting psychological strength is a crucial factor. When disappointments are longer it is best to choose IVF. 

Conclusion

In the IUI and IVF journey, reaching parenthood is an important point. Factors such as women’s age, underlying medical conditions, male infertility, and other health conditions affect the procedure of IUI and IVF. 

If you had above six IUI cycles and all were failures, then it is important to consult your healthcare advisor and decide on further steps. Compared to the method of fertilization, the ultimate goal is to step into parenthood. Hence, it is important to focus on a successful process that helps you to conceive. 

FAQs

The average cycle of an IUI is three. However, it can also last up to six cycles if the patient needs it.

According to studies, the success rate of three to four cycles is nearly 95 percent. However, it also depends on other factors.

If you are over three to four cycles and haven’t got a positive sign, then it is best to switch to IVF rather than sticking with IUI.

According to studies, the success rate of IUI in the first attempt is ten to twenty percent. Hence, three cycles are generally recommended.

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How Long Before IVF Should I Stop Smoking

How Long Before IVF Should I Stop Smoking?

Smoking is well known for its disadvantages on fertility. It can cause a reduction in sperm count and motility in men and reduced ovarian reserve and quality of eggs in women. 

For couples who are undergoing IVF, smoking can reduce the chances of pregnancy. The toxins present in cigarettes can affect every stage of the reproductive process, starting from egg and sperm quality to the development of embryos and implantation. 

This blog provides information regarding the importance of quitting smoking before going through the IVF process, how long before the procedure that smoking must be stopped, and the benefits of quitting smoking. By understanding these, couples can increase their chances of a successful IVF pregnancy.

Impact of Smoking on Fertility

Smoking can affect both female and male reproductive health in different ways. In women, it may cause a reduction in ovarian reserve that leads to reduced amounts of available eggs for fertilization. It can also affect the function of fallopian tubes, leading to an increased risk of ectopic pregnancy which should be avoided. 

In men, smoking is related to the reduction of sperm count, poor motility, and abnormal sperm morphology. All these factors combined can reduce the fertility outcome on the chances of natural pregnancy or through IVF. 

The relationship between smoking and infertility is well known. Hughes et al. (2000) have identified that only 47% of infertile smokers and 14% of pregnant smokers are recognized to have a significant impact on fertility because of smoking. Along with that, over 31% of infertile patients were informed by doctors about the risks of smoking and their causes of reproductive health.  

Smoking is related to various reproductive problems like early menopause, infertility, reduced fecundity rate, and lower success rate of IVF. In several studies, it has been identified that smokers have significantly lower chances of getting clinical pregnancy and live birth rates even with the help of IVF. 

There is also a risk of miscarriage and ectopic pregnancy. The substances in cigarette smoke, like polycystic aromatic hydrocarbons and heavy metals, can target various reproductive systems and cause harm at every stage of the process.

How Long Before IVF Should You Stop Smoking?

It is good if you could start smoking at least 4 months before getting pregnant, but stopping at any point helps.

Even low levels of smoking can affect the pregnancy and are harmful to your child. You also have a higher risk of ectopic pregnancy. However, smoking fewer cigarettes does not reduce premature birth or low-weight birth risk. 

Low-tar or low-nicotine cigarettes are also harmful to the baby as well as the mother. If you could stop smoking before you get pregnant, then the risk that is associated with it decreases.

There is also another study that states that it would be good if you could quit smoking about a month before trying to get pregnant. Generally, there should be no nicotine in your system during pregnancy. 

Nicotine is a vasoconstrictor that constricts blood vessels, including those in the placenta and baby. Smoking, as well as secondhand smoke, can increase the risk of miscarriage, birth defects, and other complications of pregnancy. There is also a possibility that they lower the odds of getting pregnant in the first place.

If the patients have stopped smoking several months before, it helps the body to detoxify and restore normal physiological function. The ovarian functions will be improved, the quality of eggs will be high, and the uterus will be more receptive to embryo implantation. 

For men, stopping smoking will increase sperm count, motility, and overall health. These factors help improve the chances of a successful and healthy pregnancy.

Strategies to Quit Smoking Before IVF

It can be challenging to stop smoking, but various strategies can help in this process.

Nicotine replacement therapy

If you are trying to get pregnant, it is safe to undergo nicotine replacement therapy.  Nicotine replacement therapy only contains low levels of nicotine and has no other damaging chemicals present in cigarettes.

Some of the products in nicotine replacement therapy include,

  • Patches
  • Nicotine chewing gum
  • Lozenges
  • Inhalators
  • Nasal or mouth spray.

Quit smoking tablets like Champix (varenicline) or Zyban (bupropion) during pregnancy. It is advisable to consult with the pharmacist or specialist about using nicotine replacement therapy products before pregnancy to stop smoking.

Liquorice-flavoured nicotine products

It is best to avoid liquorice-flavoured nicotine products if you are trying to get pregnant. Research has shown that excessive amounts of liquorice root can affect the development of the baby. 

Is it too late to stop smoking if I am already pregnant?

No, it is never too late to stop smoking. Each day the child develops in the uterus without toxins from cigarette smoke can make a difference to the health of pregnancy and more. 

Stopping smoking during the period of pregnancy can reduce the risk of the baby being ill in the first month of life. This does not mean that smoking in the first trimester is safe.  The earlier you quit smoking, the healthier you and your child will be.

Guidelines from Medical Organizations on Smoking Cessation Before IVF

Some medical organizations like the American Society of Reproductive Medicine and Society for Assisted Reproductive Technology have recommended that Individuals stop smoking before starting IVF treatment. 

The American Society of Reproductive Medicine has suggested stopping smoking at least 3 to 6 months before the IVF so it can help increase the chances of pregnancy. 

These guidelines are mainly based on the extensive research that has shown that smoking cessation can lead to improvements in the outcomes of IVF and overall reproductive health.

Conclusion

It is always encouraged to stop smoking before undergoing IVF as it can help improve the chances of a successful pregnancy. Smoking can affect reproductive health by reducing the fertility rate and decreasing the rates of healthy pregnancy. 

If a person stops smoking before starting IVF, they can significantly improve the chances of pregnancy and ensure better health for themselves and for the future baby. 

FAQs

No, even low levels of smoking can harm your fertility and IVF outcomes.

No, even occasional smoking can harm IVF outcomes.

Yes, quitting can lead to better sperm count, motility, and morphology.

Yes, both partners should quit to maximize IVF success rates.

Yes, fertility specialists can provide support and resources for quitting.

Yes, smoking can disrupt hormone levels crucial for IVF success.

How Long Before IVF Should I Stop Smoking? Read More »

How Many Times Should You Try IVF Before Giving Up

Are you tired of undergoing IVF and confused about whether you should give up? Then this article will help you make the right decision. 

IVF (In Vitro Fertilization) is the most popular choice of fertility treatment for its high success rates. However, there are instances where, no matter how many cycles you undergo, you can’t get pregnant with IVF. 

This might confuse you as to whether IVF is the right choice for you. Read this article to understand how many cycles you can undergo and when you should start looking for other treatment options. 

How Many Times Can A Woman Try IVF Before Giving Up?

There is no predetermined number of IVF cycles you can attempt to get pregnant. As long as you are healthy and your body does not have any side effects, you can undergo any number of IVF cycles you want. 

However, to be on the safer side, fertility doctors recommend an average of 3–4 IVF cycles to get pregnant. Sometimes, you might even get pregnant during your sixth cycle. 

The number of cycles you can undergo, and your success rate depends on your age and other health factors. You should discuss with your fertility doctor before determining whether you should continue your IVF cycles. 

Number Of IVF Cycles Based On A Woman’s Age

Age is the main factor that determines the number of IVF cycles you can undergo. If you don’t get pregnant within the number of cycles recommended for your age, it is best to give up on IVF and think of alternate fertility treatment options.

Age Group Average Number Of Cycles
Under 35
3–4 cycles
35–37
2–3 cycles
38–40
2 cycles
0ver 40
1 cycle

Factors Affecting The Number Of Times A Woman Can Undergo IVF

IVF failure can happen for a number of reasons. Below are some important factors that determine the number of IVF cycles you can have.

Your age

As we discussed above, your age is an important factor that determines the number of IVF cycles you undergo. This is because, as your age increases, your fertility decreases. Your health and fertility will decrease with age, reducing your IVF success and your health.

Poor egg and sperm quality

A successful IVF treatment requires high-quality eggs and sperm for successful fertilization and implantation. If either or both are of poor quality, IVF won’t succeed, no matter how many cycles you try. This can affect the number of IVF cycles you can undergo.

Health and fertility issues

Fertility issues like PCOS, endometriosis, blocked fallopian tubes, or low sperm count, and health issues like diabetes, heart problems, etc., can severely affect the number of IVF cycles you can undergo.

Discuss with your fertility doctor and analyze your condition before you undergo IVF treatments. 

When Should A Woman Quit IVF

You can undergo any number of IVF cycles you want until you get pregnant. But this is only when you are healthy and your body allows it. There are some instances when it is best to quit IVF and look for other treatment options. Below are some of those instances.

  • When you are getting older
  • When IVF treatments are affecting your health and body
  • When IVF is affecting your relationship with your partner
  • When you are in a financial crisis

Approximate Success Rate Of IVF Cycles

Considering the factors that can affect your IVF success rates, the table below depicts the average success rate you can expect during each IVF cycle.

Number of cycles Approx. success rate
1
40%
2
50%
3
55-60%
4
60–65%
5
65–70%

As you can see, your IVF success rate increases as the number of IVF cycles increases. This is one of the main reasons why doctors suggest youundergo more number of IVF cycles.

What To Do After Giving Up On IVF

IVF is not the final treatment you can undergo for infertility issues. There are other options that have a higher chance of success than traditional IVF methods. Let’s discuss those options below.

ICSI (intracytoplasmic sperm injection)

This is an advanced method of IVF where a healthy sperm is manually injected into the egg’s cytoplasm. The best sperm is injected into the best egg. This can increase your chances of a successful pregnancy.

IMSI (intracytoplasmic morphologically selected sperm injection)

IMSI is an advanced method of ICSI where the semen sample is viewed under a microscope, and the sperm with the best morphology is selected to be injected into the egg’s cytoplasm.

Donor eggs, sperm, or embryos

If you or your partner have low-quality eggs or sperm, you can choose to use donor eggs, sperm, or embryos for your fertility treatments.

Surrogacy

If you are older or have any issues that make you unable to carry the baby till full-term, you can hire a surrogate to carry and deliver the baby in your stead.

Conclusion

IVF is one of the best fertility treatment options to help you get pregnant. However, if there are any issues that cause IVF failures, it is best to analyze the condition and opt for other fertility treatments to get pregnant.

So, don’t worry if IVF does not work for you. Your fertility doctor will ensure you have a successful pregnancy and go home with a healthy baby in your arms.

FAQs

There is actually no pre-determined number of cycles you can undergo for your IVF treatments. Most doctors suggest an average number of 3–4 IVF cycles to get pregnant.

Here are some symptoms you might experience if you had a failed IVF.

  • Bleeding and spotting
  • No pregnancy symptoms
  • Negative pregnancy test
  • Cramping and pain
  • Periods

Age plays an important role in IVF success. Below is the average success rate of IVF based on a woman’s age. 

  • Women younger than 35 – 80-95%
  • 35-37 years – 70%
  • 38-40 years – 60%
  • 40-42 years – 40%
  • Over 43 years – 20%

How Many Times Should You Try IVF Before Giving Up Read More »

Are IVF injections safe

Are IVF Injections Safe?

Since its introduction, IVF (In Vitro fertilization) has become a beacon of hope for millions of infertile couples who have had difficulty conceiving. The intricate procedure and the high chances of success have attracted many couples to undergo the treatment.

However, it does not mean that the treatment is easy. Women had to undergo several complicated procedures to get pregnant. The first procedure in your IVF is the IVF injections.

In this article, we will discuss all about IVF injections and assess whether they are safe to use for women.

Assessing The Safety Of IVF Injections

IVF injection, commonly called “ovulation induction,” is the first step of the IVF procedure, where you will be administered a series of hormonal injections for a few days before egg retrieval.

These hormonal injections stimulate the ovaries to produce more mature eggs. These eggs will be retrieved and used for fertilization.

It is normal for you to feel anxious about taking hormonal injections. However, they are fairly safe and only cause minor side effects (which we will discuss below).

Here is a breakdown of the safety aspects of IVF injections.

Expert handling

Your IVF treatment will be performed by an expert fertility specialist. So, you don’t need to worry about safety while taking the injections.

Close monitoring

Your egg’s development and body’s reaction to the injections will be closely monitored regularly. So, if you appear to have any adverse reactions, they will be immediately identified and treated. 

The injections are mostly tolerable

Most women who have undergone IVF before have reported that the injections are fairly tolerable and only mildly painful. 

Temporary side effects

Even if you experience any side effects due to the procedure, they are temporary and will disappear in a few days. 

Common Side Effects Of IVF Injections For Pregnancy

So far, we have discussed how the side effects of IVF injections are minor and will disappear in a few days. Below are some of the side effects you might get during IVF injections. 

  • Redness, swelling, and light bruising in the injection site
  • Mild abdominal discomfort
  • Mood swings
  • Tender breasts
  • Nausea and bloating
  • Hot flashes

These are some minor side effects of IVF injections. However, sometimes, you might also get some serious side effects like Ovarian Hyperstimulation Syndrome (OHSS), where your ovaries get swollen and painful because they overreact to the injections.

Conclusion

IVF injections are crucial for the success of your IVF treatments. They are essential for producing more eggs and increasing your chances of having a successful pregnancy.

If you are worried about the side effects of the injections, don’t worry. Consult your fertility doctor or a psychologist and understand ways to make the procedure as painless as possible.

FAQs

Yes, though IVF has a higher success rate than other treatments, it has certain risks and complications. These risks depend on your health and fertility condition and is not the same in every women.

Below are some of the side effects you might get during IVF injections. 

  • Redness, swelling, and light bruising in the injection site
  • Mild abdominal discomfort
  • Mood swings
  • Tender breasts
  • Nausea and bloating
  • Hot flashes
  • OHSS (Ovarian Hyperstimulation Syndrome)

IVF injections is a very important process. Your body will be undergoing rapid hormonal changes during this period. During this period, avoid meat, fish, processed or junk food, alcohol, cigarettes, and other harmful habits.

The number of injections for each woman differs according to their fertility condition. On average, a woman is required to take a total of 80–90 shots (1 or 2 per day) during IVF injections.

Are IVF Injections Safe? Read More »

High Blood Pressure Before IVF

One of the health conditions that is common worldwide is high blood pressure or hypertension. While trying for in vitro fertilization (IVF), it is crucial to maintain blood pressure for the health of both baby and mother.

This blog will help you understand the relationship between IVF and blood pressure and help you learn about strategies, risks, and management.

High Blood Pressure

High blood pressure occurs when the blood pressure on the artery wall is too high. Hypertension has no visible symptoms; hence, it is also known as the “silent killer.”

However, this one symptom can lead to other diseases, such as stroke, kidney failure, and heart disease.

Blood pressure is measured in millimeters of mercury, which is denoted as (mm Hg). This is measured using systolic and diastolic pressure. The general blood pressure is usually below 120/80 mm Hg; however, for hypertension, it is 130/80 mm Hg mm or higher.

Connection Between Fertility and High Blood Pressure

Hypertension affects both women and men. However, in women, hypertension can have negative effects, leading to irregular menstrual cycles or ovulation problems, making it harder for women to conceive.

Moreover, medications used to treat blood pressure can often interfere with fertility. In men, hypertension affects sperm quality, leading to complications in pregnancy.

Blood pressure and IVF

IVF is a tough process that includes various steps. This includes hormone treatment, egg retrieval, fertilization, embryo culture, and embryo transfer. However, for couples with high blood pressure, IVF can be a physically and emotionally demanding process.

Risk Related to High Blood Pressure and IVF

Some of the risks associated with high blood pressure and IVF are described below:

Complications in Pregnancy

Women with hypertension can have complications during pregnancy, namely preeclampsia. Preeclampsia is a condition that damages the organs, commonly the kidney or the liver of the baby. Moreover, it can be fatal sometimes for both the baby and the mother if not treated or diagnosed.

Decreased Blood Flow to the Uterus

Hypertension puts a lot of pressure on the artery wall; hence, there is a decrease in blood flow to the uterus, where the embryo will be implanted. This often increases the chance of miscarriage.

Preterm Birth

A normal and healthy pregnancy happens after forty weeks. However, high blood pressure can lead to delivery on or before thirty-seven weeks of pregnancy. This could lead to reduced weight and developmental problems in the baby.

Placental Abruption

Placental abruption means that the placenta separates itself from the uterus before pregnancy. This puts both the mother and baby in danger due to heavy bleeding.

Cardiovascular Risks

In IVF, hormonal inductions are often used to promote ovulation. Sometimes, these drugs can impact blood pressure, leading to stroke or other cardiovascular conditions in women.

Impact on Positive Results

Researchers have discussed that hypertension has an impact on IVF green signs. Women with low blood pressure have higher success rates compared to women with higher blood pressure.

How to Manage High Blood Pressure Before an IVF?

Individuals should be aware of the risks and treatment process of IVF to increase success rates. Some of the management steps are listed below:

Modification in Lifestyle

Lifestyle plays a crucial role in women and men with hypertension. It is important to eat fruits and vegetables and have a diet low in salt. Engage in physical activity daily. You can also practice yoga or meditation to manage your stress level. Avoid smoking and alcohol.

Management Through Medication

Hypertension can be managed by using medications. However, some medications can interfere with the IVF treatment. Hence, it is important to sit with your fertilty doctor and modify your medication by checking your condition. Additionally, it is vital to be true to your doctors about your condition. This helps to understand the condition better.

Individualized Care

There is no one-size-fits-all in IVF. Hence, it is important to create a curated plan according to the needs of an individual. It is important to trust the experts and follow their recommendations to improve your health.

Consider Emotional Support

IVF is a rollercoaster process. It is both emotionally and physically demanding, specifically if you have certain underlying conditions like hypertension. It is always better to rely on support groups or people you trust. You can also look for professional help when needed, as you may gain some valuable insights and encouragement.

Conclusion

IVF offers hope to couples who cannot conceive naturally. It is their gate to parenthood. However, underlying conditions, namely hypertension, slim the chances of IVF success.

This is because the drugs interfere with the IVF process, or there is a decreased blood flow to the uterus.

However, the process can be maintained before IVF through a proper diagnosis. It is important to maintain a healthy diet, exercise, meditation, and medical management. There is always a light in the process, and it is important to be patient to reach the place.

FAQs

Yes, women with hypertension can do IVF. However, the process should be monitored closely to avoid any further complications during pregnancy.

High blood pressure can have some negative effects on implantation. This includes reduced blood flow to the uterus affecting the process of ovulation and implantation.

There are certain complications that a mother can experience due to hypertension, including placental abruption, stroke, and preeclampsia.

A small group of studies indicates that a woman’s blood pressure increases slightly during ovulation, and this may be due to hormonal changes in the body.

High Blood Pressure Before IVF Read More »

What To Do Before Embryo Transfer To Increase Success

Are you preparing for embryo transfer? Are you confused about what you should do and worried you might do something that can affect IVF success rates? Then, this article is for you.

In this article, you will learn some important tips you can follow to increase your chances of a successful pregnancy. Read till the end and ensure you follow it before embryo transfer.

What To Do Before Embryo Transfer To Increase Success Rate?

Follow A Healthy Diet

Focus on eating a healthy, nutritious diet before your embryo transfer. Include lots of fruits, vegetables, whole grains, and other foods that can improve your health and fertility. 

The food you eat before embryo transfer gives you the strength and energy you need during embryo transfer. It is also necessary to avoid foods that can negatively impact embryo implantation and cause complications. 

Below are some foods you can consume before embryo transfer. 

  • Warm soups
  • Lemon water
  • Fresh fruits and vegetables
  • Lean proteins like chicken breast, fish, etc.
  • Whole grains like quinoa, brown rice, whole-wheat bread, etc.
  • Legumes like lentils, beans, chickpeas, etc.
  • Healthy fats like walnuts, almonds, seeds, avocado, olive oil, etc.

Below are some foods you should definitely avoid before embryo transfer.

  • Sugary foods
  • Cold beverages like sodas and smoothies
  • Red meat
  • Processed, fried, or junk foods
  • Salty foods
  • Caffeinated drinks
  • Alcohol 

Do Regular Exercises

Whether it is before, during, or after embryo transfer, it is always best to keep yourself active and engage in moderate exercises. Regular exercise can improve blood circulation and reduce stress. It can also help you maintain a healthy BMI.

Aim for at least 30 minutes of moderate exercises at least 4 days a week. You can do exercises like walking, yoga, swimming, zumba, aerobics, etc. You can also consult your doctor or fitness coach to design a customized exercise plan for you.

Note: Ensure that you only do low or moderate-intensity exercises. Do not engage in high-intensity workouts. This can cause the opposite effect of what you wanted.

Get Adequate Sleep

Adequate sleep is necessary to ensure a healthy metabolism and bodily functions. According to studies, women getting less sleep have a 15% lesser chance of IVF success than those getting adequate sleep.

Ensure you aim for at least 7–8 hours of sleep every day. If you have trouble falling asleep, consult your doctor and get some medications to induce sleep. Don’t buy sleep medications at the medical store by yourself. It can have components that can affect IVF success rate.

Drink Lots Of Water

Hydration is key for a healthy body and hormonal functions. Ensure you drink lots of water throughout the day and stay hydrated (aim for at least 2 litres of water per day). You can also drink other liquids, like fruit juices, milk, etc., to stay fresh and hydrated.

Manage Stress

Stress is one of the most important factors affecting your fertility and IVF success. Stress can negatively affect your hormonal balance and decrease your chances of healthy implantation and pregnancy.

Stay calm and practice relaxation techniques like yoga, meditation, deep breathing, mindfulness, etc. You can also engage in activities that you like (reading, gardening, painting, etc.) to relieve stress.

Avoid Exposure To Harmful Chemicals (EDCs)

Endocrine-Disrupting Chemicals (EDCs) are harmful chemicals that can affect your hormonal and reproductive health. This can severely affect your chances of a healthy pregnancy.

Some harmful EDCs include parabens, formaldehyde, triclosan, benzophenone, and dioxins. These chemicals can be found in day-to-day products like shampoos and fertilizers. So, ensure you only use products that are free of these chemicals.

Take The Prescribed Supplements On Time

Your fertility doctor will prescribe certain medications for you to prepare your uterus and improve implantation rates. These supplements include folic acid, Vitamin D, antioxidants, etc. Ensure you take all those medications on time.

Also, don’t consume any medications you buy over the counter at a medical store for issues like cough, cold, etc. Always consult your doctor if you have any issues that need medication.

Follow Your Doctor’s Instructions

Your fertility doctor will analyze your fertility condition and recommend some things you can and cannot do during the treatment. Remember that these things are to increase your chances of having a successful pregnancy.

Ensure you follow your doctor’s instructions and don’t do anything they advise against. And remember to adhere to follow-up appointments, schedules, and other guidelines they provide.

Conclusion

The above points discussed are some of the most important measures you need to take before an embryo transfer. Remember, embryo transfer is the most important step of your IVF treatment.

So, it is essential for you to do everything you can to ensure a higher success rate. If you have any doubts or concerns, consult your fertility doctor immediately.

FAQs

 

Below are some foods you should definitely avoid before embryo transfer.

  • Sugary foods
  • Cold beverages like sodas and smoothies
  • Red meat
  • Processed, fried, or junk foods
  • Salty foods
  • Caffeinated drinks
  • Alcohol

Adequate sleep is necessary to ensure a healthy metabolism and bodily functions. According to studies, women getting less sleep have a 15% lesser chance of IVF success than those getting adequate sleep. Ensure you aim for at least 7–8 hours of sleep every day.

Endocrine-Disrupting Chemicals (EDCs) are harmful chemicals that can affect your hormonal and reproductive health. Some harmful EDCs include parabens, formaldehyde, triclosan, benzophenone, and dioxins. These chemicals can be found in day to day products like shampoos and fertilizers.

What To Do Before Embryo Transfer To Increase Success Read More »

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