Ovulation Induction in Chennai

The most common cause is polycystic ovary syndrome (PCOS), which accounts for roughly 80 percent of anovulatory infertility. Other causes include hypothalamic dysfunction from stress or weight changes, high prolactin levels, and thyroid disorders. If you have irregular or absent periods, you likely are not ovulating consistently and may benefit from ovulation induction.

Current evidence favours letrozole as the first-line choice, especially for PCOS patients. Letrozole produces higher ovulation and pregnancy rates with a lower risk of multiple follicle development and twins. It also has a shorter half-life, clearing the body faster and having less anti-estrogenic effect on the endometrium.

Most pregnancies from ovulation induction occur within the first four to six ovulatory cycles. If you have ovulated regularly with medication for four to six cycles without conceiving, Dr. Rukkayal will discuss adding IUI or transitioning to IVF rather than continuing the same approach indefinitely.

Monitoring ensures that the medication is producing the right number of follicles — ideally one or two. Without monitoring, there is a risk of multiple pregnancies from uncontrolled multi-follicle development. Ultrasound also confirms that ovulation actually occurs and that the endometrial lining is developing appropriately for implantation.

With proper monitoring and dose control, the twin rate with letrozole is approximately 5 to 7 percent — only slightly above the natural rate. Clomiphene carries a slightly higher twin risk of 8 to 10 percent. Dr. Rukkayal will cancel the cycle or advise barrier contraception if too many follicles develop, prioritising your safety.

Yes — ovulation induction is the primary treatment for PCOS-related infertility. Letrozole is particularly effective in PCOS, with ovulation rates of 60 to 80 percent and pregnancy rates comparable to more invasive treatments. Addressing insulin resistance and optimising weight before starting medication further improves outcomes.

If letrozole and clomiphene do not produce adequate follicle growth, low-dose injectable gonadotropins are the next step. These require more intensive monitoring but can effectively induce ovulation in resistant cases. If injectable medications also fail, ovarian drilling or IVF may be considered.

Common side effects include mild hot flashes, headache, and occasional mood changes. Letrozole tends to have fewer side effects than clomiphene. Serious complications like ovarian hyperstimulation are rare with oral medications and careful monitoring. Dr. Rukkayal discusses all potential side effects before starting treatment.